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NFKBIA Antibody

Mouse Monoclonal Antibody (Mab)

     
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  • 1 - NFKBIA Antibody AW5063
    Western blot analysis of lysates from Hela,mouse NIH/3T3 cell line (from left to right), using NFKBIA Antibody(Cat. #AW5063). AW5063 was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysates at 20ug per lane.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P25963
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1,κ
Clone Names 1121CT8.6.1
Calculated MW H=36;M=35 KDa
Additional info
Gene ID 4792
Other Names NFKBIA;IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; NF-kappa-B inhibitor alpha; Major histocompatibility complex enhancer-binding protein MAD3
Target/Specificity Purified His-tagged NFKBIA protein was used to produced this monoclonal antibody.
Dilution WB~~1:1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNFKBIA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NFKBIA
Synonyms IKBA, MAD3, NFKBI
Function Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Cellular Location Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
Research Areas

BACKGROUND

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

REFERENCES

Huxford T., et al. Cell 95:759-770(1998).
Cockman M.E., et al. Proc. Natl. Acad. Sci. U.S.A. 103:14767-14772(2006).
Haskill S., et al. Cell 65:1281-1289(1991).
Jungnickel B., et al. J. Exp. Med. 191:395-402(2000).
Liu B., et al. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.

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