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VEGFC Antibody

Mouse Monoclonal Antibody (Mab)

     
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  • 1 - VEGFC Antibody AW5055
    Western blot analysis of lysates from rat heart tissue,CEM cell line, mouse heart tissue(from left to right), using VEGFC Antibody(Cat. #AW5055). AW5055 was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysates at 20ug per lane.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P49767
Other Accession NP_005420.1
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG1,K
Clone Names 197CT7.3.4
Calculated MW H=47;M=46;Rat=46 KDa
Additional info
Gene ID 7424
Other Names VEGFC; Vascular endothelial growth factor C; Flt4 ligand; Vascular endothelial growth factor-related protein
Target/Specificity This VEGFC monoclonal antibody is generated from mouse immunized with VEGFC recombinant protein.
Dilution WB~~1:1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsVEGFC Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VEGFC
Function Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
Cellular Location Secreted.
Tissue Location Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte
Research Areas

BACKGROUND

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D. [provided by RefSeq].

REFERENCES

Chen, X., et al. Cancer Sci. 101(11):2384-2390(2010)
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Deguchi, K., et al. Anticancer Res. 30(6):2361-2366(2010)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :

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