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CFL2 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - CFL2 Antibody (C-term) AW5036
    Western blot analysis of lysates from human skeletal muscle and mouse brain tissue lysate (from left to right), using CFL2 Antibody (C-term)(Cat. #AW5036). AW5036 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
  • 3 - CFL2 Antibody (C-term) AW5036
    Fluorescent image of Hela cells stained with CFL2 Antibody (C-term)(Cat#AW5036). AW5036 was diluted at 1:25 dilution. An Alexa Fluor 488-conjugated goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody (green). Cytoplasmic actin was counterstained with Alexa Fluor® 555 conjugated with Phalloidin (red).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IF
Primary Accession Q9Y281
Other Accession Q5XHH8, Q5G6V9, P45591, P21566, Q148F1
Reactivity Human, Mouse
Predicted Bovine, Chicken, Xenopus
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Clone Names RB48609
Calculated MW H=19,17;M=19 KDa
Additional info
Gene ID 1073
Other Names Cofilin-2, Cofilin, muscle isoform, CFL2
Target/Specificity This CFL2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 130-144 amino acids from the C-terminal region of human CFL2.
Dilution WB~~1:1000
IF~~1:25
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCFL2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CFL2
Function Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity).
Cellular Location Nucleus matrix. Cytoplasm, cytoskeleton
Tissue Location Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues
Research Areas

BACKGROUND

Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity).

REFERENCES

Jin J.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Thirion C.,et al.Eur. J. Biochem. 268:3473-3482(2001).
Heilig R.,et al.Nature 421:601-607(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (MAR-2008) to UniProtKB.

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