|Application ||IF, WB|
|Other Accession||Q5XHH8, Q5G6V9, P45591, P21566, Q148F1|
|Predicted||Bovine, Chicken, Xenopus|
|Calculated MW||H=19,17;M=19 KDa|
|Other Names||Cofilin-2, Cofilin, muscle isoform, CFL2|
|Target/Specificity||This CFL2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 130-144 amino acids from the C-terminal region of human CFL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CFL2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity).|
|Cellular Location||Nucleus matrix. Cytoplasm, cytoskeleton|
|Tissue Location||Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues|
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity).
Jin J.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Thirion C.,et al.Eur. J. Biochem. 268:3473-3482(2001).
Heilig R.,et al.Nature 421:601-607(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (MAR-2008) to UniProtKB.