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TRPV6 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - TRPV6 Antibody (Center) AW5014
    Western blot analysis of lysates from human placenta,liver,kidney,testis tissue and SW480 cell line (from left to right),using TRPV6 Antibody (Center)(Cat. #AW5014). AW5014 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q9H1D0
Reactivity Human
Host Rabbit
Clonality polyclonal
Calculated MW H=83,64 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 55503
Antigen Region 352-385
Other Names Transient receptor potential cation channel subfamily V member 6, TrpV6, CaT-like, CaT-L, Calcium transport protein 1, CaT1, Epithelial calcium channel 2, ECaC2, TRPV6, ECAC2
Dilution WB~~1:1000
Target/Specificity This TRPV6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 352-385 amino acids from the Central region of human TRPV6.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTRPV6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRPV6
Synonyms ECAC2
Function Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin- dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but not detected in healthy prostate tissue and benign prostatic hyperplasia
Research Areas

BACKGROUND

Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin- dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).

REFERENCES

Peng J.-B.,et al.Biochem. Biophys. Res. Commun. 278:326-332(2000).
Wood R.J.,et al.BMC Physiol. 1:11-11(2001).
Peng J.-B.,et al.Genomics 76:99-109(2001).
Wissenbach U.,et al.J. Biol. Chem. 276:19461-19468(2001).
Peng J.-B.,et al.Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.

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