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HIST1H2BM Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - HIST1H2BM Antibody (N-term) AW5002
    Western blot analysis of lysates from human skeletal muscle tissue and PC-3, K562 cell line (from left to right), using HIST1H2BM Antibody (N-term)(Cat. #AW5002). AW5002 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q99879
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality polyclonal
Calculated MW H=14;M=14 KDa
Isotype Rabbit Ig
Antigen Source HUMAN
Additional Information
Gene ID 8342
Antigen Region 10-44
Other Names Histone H2B type 1-M, Histone H2Be, H2B/e, HIST1H2BM, H2BFE
Dilution WB~~1:1000
Target/Specificity This HIST1H2BM antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 10-44 amino acids from the N-terminal region of human HIST1H2BM.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHIST1H2BM Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HIST1H2BM
Synonyms H2BFE
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Cellular Location Nucleus. Chromosome.

BACKGROUND

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

REFERENCES

Albig W.,et al.Hum. Genet. 101:284-294(1997).
Marzluff W.F.,et al.Genomics 80:487-498(2002).
Mungall A.J.,et al.Nature 425:805-811(2003).
Lubec G.,et al.Submitted (MAR-2007) to UniProtKB.
Cheung W.L.,et al.Cell 113:507-517(2003).

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