癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
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MAP3K13 (LZK) Antibody (C-term)
Mouse Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| IF, WB, E |
|---|---|
| Primary Accession | O43283 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Polyclonal |
| Isotype | IgM |
| Gene ID | 9175 |
|---|---|
| Other Names | Mitogen-activated protein kinase kinase kinase 13, Leucine zipper-bearing kinase, Mixed lineage kinase, MLK, MAP3K13 (HGNC:6852) |
| Target/Specificity | Purified His-tagged MAP3K13 protein was used to produced this monoclonal antibody. |
| Dilution | WB~~1:500 IF~~1:100 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MAP3K13 (LZK) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAP3K13 (HGNC:6852) |
|---|---|
| Function | Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. |
| Cellular Location | Cytoplasm. Membrane; Peripheral membrane protein |
| Tissue Location | Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas |
Research Areas
BACKGROUND
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.
REFERENCES
Ikeda A., et al. J. Biochem. 130:773-781(2001).
Masaki M., et al. Eur. J. Biochem. 270:76-83(2003).
Greenman C., et al. Nature 446:153-158(2007).
Sakuma H., et al. J. Biol. Chem. 272:28622-28629(1997).
Ota T., et al. Nat. Genet. 36:40-45(2004).
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