MAP3K13 (LZK) Antibody (C-term)
Mouse Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| WB, IF, E |
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Primary Accession | O43283 |
Reactivity | Human |
Host | Mouse |
Clonality | Polyclonal |
Isotype | IgM |
Gene ID | 9175 |
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Other Names | Mitogen-activated protein kinase kinase kinase 13, Leucine zipper-bearing kinase, Mixed lineage kinase, MLK, MAP3K13 (HGNC:6852) |
Target/Specificity | Purified His-tagged MAP3K13 protein was used to produced this monoclonal antibody. |
Dilution | WB~~1:500 IF~~1:100 |
Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MAP3K13 (LZK) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MAP3K13 (HGNC:6852) |
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Function | Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. |
Cellular Location | Cytoplasm. Membrane; Peripheral membrane protein |
Tissue Location | Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas |
Research Areas
BACKGROUND
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.
REFERENCES
Ikeda A., et al. J. Biochem. 130:773-781(2001).
Masaki M., et al. Eur. J. Biochem. 270:76-83(2003).
Greenman C., et al. Nature 446:153-158(2007).
Sakuma H., et al. J. Biol. Chem. 272:28622-28629(1997).
Ota T., et al. Nat. Genet. 36:40-45(2004).

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