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THOC7 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - THOC7 Antibody (C-term) AP9905b
    Western blot analysis of THOC7 Antibody (C-term) (Cat. #AP9905b) in mouse spleen tissue lysates (35ug/lane). THOC7 (arrow) was detected using the purified Pab.
  • 4 - THOC7 Antibody (C-term) AP9905b
    THOC7 Antibody (C-term) (Cat. #AP9905b) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, FC, E
Primary Accession Q6I9Y2
Other Accession Q7TMY4, Q3SZ60
Reactivity Human, Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 23743 Da
Additional info
Gene ID 80145
Other Names THO complex subunit 7 homolog, Functional spliceosome-associated protein 24, fSAP24, Ngg1-interacting factor 3-like protein 1-binding protein 1, NIF3L1-binding protein 1, hTREX30, THOC7, NIF3L1BP1
Target/Specificity This THOC7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-166 amino acids from the C-terminal region of human THOC7.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTHOC7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name THOC7
Synonyms NIF3L1BP1
Function Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.
Cellular Location Cytoplasm. Nucleus. Nucleus speckle Note=Interaction with THOC5 is required for nuclear localization
Research Areas
An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5.
Author : Ramachandran S1, Tran DD, Klebba-Faerber S, Kardinal C, Whetton AD, Tamura T.
RNA. 2011 Nov;17(11):1957-66. doi: 10.1261/rna.2820911. Epub 2011 Sep 21.
21937706
Human corneal endothelial cells employ phosphorylation of p27(Kip1) at both Ser10 and Thr187 sites for FGF-2-mediated cell proliferation via PI 3-kinase.
Author : Lee JG, Song JS, Smith RE, Kay EP.
Invest Ophthalmol Vis Sci. 2011 Oct 17;52(11):8216-23. doi: 10.1167/iovs.11-8213.
21948550

REFERENCES

El Bounkari, O., et al. FEBS Lett. 583(1):13-18(2009)
Boyne, J.R., et al. PLoS Pathog. 4 (10), E1000194 (2008)
Cheng, H., et al. Cell 127(7):1389-1400(2006)
Masuda, S., et al. Genes Dev. 19(13):1512-1517(2005)

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