|Application ||WB, FC, E|
|Other Names||Rho GTPase-activating protein 19, Rho-type GTPase-activating protein 19, ARHGAP19|
|Target/Specificity||This RHG19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-224 amino acids from the Central region of human RHG19.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RHG19 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.|
|Tissue Location||Strong expression in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Weak expression in adult pancreas, spleen, thymus, and ovary|
Provided below are standard protocols that you may find useful for product applications.
Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression.
Lv, L., et al. DNA Seq. 18(3):184-189(2007)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Deloukas, P., et al. Nature 429(6990):375-381(2004)
Jikuya, H., et al. DNA Res. 10(1):49-57(2003)