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hPFTK1-M1 Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - hPFTK1-M1 Antibody AP9800b
    Western blot analysis of hPFTK1-M1 (Cat. #AP9800b) in mouse liver tissue lysates (35ug/lane). PFTK1 (arrow) was detected using the purified Pab.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession O94921
Other Accession B6A7Q3, O35495, NP_036527
Reactivity Human, Mouse
Predicted Rabbit
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 53057 Da
Additional info
Gene ID 5218
Other Names Cyclin-dependent kinase 14, Cell division protein kinase 14, Serine/threonine-protein kinase PFTAIRE-1, hPFTAIRE1, CDK14, KIAA0834, PFTK1
Target/Specificity This hPFTK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from human hPFTK1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionshPFTK1-M1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDK14
Synonyms KIAA0834, PFTK1
Function Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
Cellular Location Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell membrane by CCNY
Tissue Location Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected.
Research Areas

BACKGROUND

PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family.

REFERENCES

Malumbres, M., et al. Nat. Cell Biol. 11(11):1275-1276(2009)
Jiang, M., et al. FEBS Lett. 583(13):2171-2178(2009)
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Denoeud, F., et al. Genome Res. 17(6):746-759(2007)
Shu, F., et al. Proc. Natl. Acad. Sci. U.S.A. 104(22):9248-9253(2007)

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