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|Application ||WB, IHC-P, E|
|Other Names||Stimulated by retinoic acid gene 6 protein homolog, STRA6|
|Target/Specificity||This STRA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-614 amino acids from the C-terminal region of human STRA6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||STRA6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Broad expression. In adult eye expressed in sclera, retina, retinal pigment epithelium, and trabecular meshwork but not in choroid and iris|
Author : Chen CH1, Ke LY1, Chan HC1, Lee AS2, Lin KD1, Chu CS1, Lee MY1, Hsiao PJ1, Hsu C1, Chen CH3, Shin SJ4.
J Lipid Res. 2016 Jun 2. pii: jlr.M067215. [Epub ahead of print]
Provided below are standard protocols that you may find useful for product applications.
STRA6 is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9).
Chassaing, N., et al. Hum. Mutat. 30 (5), E673-E681 (2009)
West, B., et al. Am. J. Med. Genet. A 149A (3), 539-542 (2009)
Kawaguchi, R., et al. J. Biol. Chem. 283(22):15160-15168(2008)
Isken, A., et al. Cell Metab. 7(3):258-268(2008)
White, T., et al. Mol. Vis. 14, 2458-2465 (2008)