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STRA6 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - STRA6 Antibody (C-term) AP9433b
    Western blot analysis of STRA6 Antibody (C-term) (Cat. #AP9433b) in Hela cell line lysates (35ug/lane). UBAC1 (arrow) was detected using the purified Pab;
  • 1 - STRA6 Antibody (C-term) AP9433b
    Western blot analysis of STRA6 Antibody (C-term) (Cat. #AP9433b) in mouse bladder tissue lysates (35ug/lane). STRA6 (arrow) was detected using the purified Pab.
  • 14 - STRA6 Antibody (C-term) AP9433b
    Formalin-fixed and paraffin-embedded human hepatocarcinoma with STRA6 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q9BX79
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 64220
Other Names Stimulated by retinoic acid gene 6 protein homolog, STRA6
Target/Specificity This STRA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-614 amino acids from the C-terminal region of human STRA6.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSTRA6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STRA6
Function May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Broad expression. In adult eye expressed in sclera, retina, retinal pigment epithelium, and trabecular meshwork but not in choroid and iris
Research Areas
Electronegative Low-Density Lipoprotein Induces Renal Apoptosis and Fibrosis: STRA6 Signaling Involved.
Author : Chen CH1, Ke LY1, Chan HC1, Lee AS2, Lin KD1, Chu CS1, Lee MY1, Hsiao PJ1, Hsu C1, Chen CH3, Shin SJ4.
J Lipid Res. 2016 Jun 2. pii: jlr.M067215. [Epub ahead of print]
27256691

BACKGROUND

STRA6 is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9).

REFERENCES

Chassaing, N., et al. Hum. Mutat. 30 (5), E673-E681 (2009)
West, B., et al. Am. J. Med. Genet. A 149A (3), 539-542 (2009)
Kawaguchi, R., et al. J. Biol. Chem. 283(22):15160-15168(2008)
Isken, A., et al. Cell Metab. 7(3):258-268(2008)
White, T., et al. Mol. Vis. 14, 2458-2465 (2008)

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