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>   首页   >   产品   >   一抗   >   精选抗体   >   G蛋白偶联受体抗体(GPCR)   >   MTNR1A Antibody (Center)   

MTNR1A Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - MTNR1A Antibody (Center) AP9283c
    Western blot analysis of MTNR1A Antibody (Center) (Cat. #AP9283c) in CEM cell line lysates (35ug/lane). MTNR1A (arrow) was detected using the purified Pab.
  • 4 - MTNR1A Antibody (Center) AP9283c
    MTNR1A Antibody (Center) (Cat. #AP9283c) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, FC, E
Primary Accession P48039
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 4543
Other Names Melatonin receptor type 1A, Mel-1A-R, Mel1a receptor, MTNR1A
Target/Specificity This MTNR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-229 amino acids from the Central region of human MTNR1A.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMTNR1A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MTNR1A
Function High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus
Research Areas

BACKGROUND

MTNR1A encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.

REFERENCES

Adi,N., et.al., Med. Sci. Monit. 16 (2), BR61-BR67 (2010)
Hill,S.M., et.al., Integr Cancer Ther 8 (4), 337-346 (2009)
Lai,L., et.al., Breast Cancer Res. Treat. 118 (2), 293-305 (2009)

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