|Application ||WB, E|
|Calculated MW||21365 Da|
|Other Names||Histone H12, Histone H1c, Histone H1d, Histone H1s-1, HIST1H1C, H1F2|
|Target/Specificity||This HIST1H1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-131 amino acids from the Central region of human HIST1H1C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HIST1H1C Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).|
|Cellular Location||Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Distribution goes in parallel with DNA concentration|
Provided below are standard protocols that you may find useful for product applications.
Histones H1 are necessary for the condensation of nucleosome chains into higher order structures.
Mayya V., et.al., Sci. Signal. 2:RA46-RA46(2009).