- 文献引用 : 1
|Application ||WB, E|
|Other Accession||G3V735, Q8K371, F1MRK3|
|Other Names||Angiomotin-like protein 2, Leman coiled-coil protein, LCCP, AMOTL2, KIAA0989|
|Target/Specificity||This AMOTL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-152 amino acids from the Central region of human AMOTL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AMOTL2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.|
|Cellular Location||Recycling endosome.|
Author : Proszynski TJ1, Sanes JR.
J Cell Sci. 2013 May 15;126(Pt 10):2225-35. doi: 10.1242/jcs.121327. Epub 2013 Mar 22.
Provided below are standard protocols that you may find useful for product applications.
AMOTL2 is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family.
Bratt,A.,et.al., Gene 298 (1), 69-77 (2002)