|Application ||WB, IHC-P, FC, E|
|Other Accession||A1L3L9, P36877, Q00006, P54614, Q6ZWR4, Q4R8L3, Q5E9Q7|
|Predicted||Bovine, Mouse, Pig, Monkey, Rat, Rabbit, Xenopus|
|Calculated MW||51710 Da|
|Other Names||Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform, PP2A subunit B isoform B55-beta, PP2A subunit B isoform PR55-beta, PP2A subunit B isoform R2-beta, PP2A subunit B isoform beta, PPP2R2B|
|Target/Specificity||This PPP2R2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-130 amino acids from the Central region of human PPP2R2B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PPP2R2B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity).|
|Cellular Location||Isoform 1: Cytoplasm. Cytoplasm, cytoskeleton. Membrane|
Provided below are standard protocols that you may find useful for product applications.
PPP2R2B belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This protein is a beta isoform of the regulatory subunit B55 subfamily.
Rajkiewicz,M., et.al., Neurol. Neurochir. Pol. 42 (6), 497-504 (2008)
Ben-Israel,H., et.al., J. Virol. 82 (19), 9381-9388 (2008)
Strack,S., et.al., J. Comp. Neurol. 392 (4), 515-527 (1998)