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PFKFB1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 14 - PFKFB1 Antibody (Center) AP8147c
    Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with PFKFB1 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • 1 - PFKFB1 Antibody (Center) AP8147c
    Western blot analysis of anti-PFKFB1 Antibody (Center) (Cat.#AP8147c) in Jurkat cell line lysates (35ug/lane). PFKFB1(arrow) was detected using the purified Pab.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, WB, E
Primary Accession P16118
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 54681 Da
Additional info
Gene ID 5207
Other Names 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1, 6PF-2-K/Fru-2, 6-P2ase 1, PFK/FBPase 1, 6PF-2-K/Fru-2, 6-P2ase liver isozyme, 6-phosphofructo-2-kinase, Fructose-2, 6-bisphosphatase, PFKFB1, F6PK, PFRX
Target/Specificity This PFKFB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 259-289 amino acids from the Central region of human PFKFB1.
Dilution IHC-P~~1:50~100
WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPFKFB1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PFKFB1
Synonyms F6PK, PFRX
Function Synthesis and degradation of fructose 2,6-bisphosphate.
Tissue Location Liver.
Research Areas

BACKGROUND

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).

REFERENCES

Algaier, J., et al., Biochem. Biophys. Res. Commun. 153(1):328-333 (1988). Lange, A.J., et al., Nucleic Acids Res. 18 (12), 3652 (1990).

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