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ALDH3A1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - ALDH3A1 Antibody (Center) AP7849c
    Anti-ALDH3A1 Antibody (Center) at 1:1000 dilution + human lung lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 50 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - ALDH3A1 Antibody (Center) AP7849c
    ALDH3A1 Antibody (Center) (Cat. #AP7849c) western blot analysis in A549,Daudi,Hela cell line lysates (35ug/lane).This demonstrates the ALDH3A1 antibody detected the ALDH3A1 protein (arrow).
  • 14 - ALDH3A1 Antibody (Center) AP7849c
    Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with ALDH3A1 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, WB, E
Primary Accession P30838
Other Accession P30907
Reactivity Human
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 50395 Da
Additional info
Gene ID 218
Other Names Aldehyde dehydrogenase, dimeric NADP-preferring, ALDHIII, Aldehyde dehydrogenase 3, Aldehyde dehydrogenase family 3 member A1, ALDH3A1, ALDH3
Target/Specificity This ALDH3A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 254-284 amino acids from the Central region of human ALDH3A1.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsALDH3A1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALDH3A1
Synonyms ALDH3
Function ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:P47739}.
Tissue Location High levels in stomach, esophagus and lung; low level in the liver and kidney
Research Areas
Aldehyde dehydrogenase 3A1 promotes multi-modality resistance and alters gene expression profile in human breast adenocarcinoma MCF-7 cells.
Author : Voulgaridou GP1, Kiziridou M1, Mantso T2, Chlichlia K1, Galanis A1, Koukourakis MI3, Franco R4, Panayiotidis MI5, Pappa A6.
Int J Biochem Cell Biol. 2016 Jun 5. pii: S1357-2725(16)30138-8. doi: 10.1016/j.biocel.2016.06.004. [Epub ahead of print]
27276244

BACKGROUND

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. ALDH3A1 forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. The enzyme is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea.

REFERENCES

Glatt,H., Arch. Biochem. Biophys. 477 (2), 196-205 (2008)
Ekhart,C., Pharmacogenet. Genomics 18 (6), 515-523 (2008)
Giebultowicz,J., Acta Pol Pharm 65 (1), 81-84 (2008)

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