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NGFB Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - NGFB Antibody (Center) AP7771c
    Western blot analysis of NGFB Antibody (Center) (Cat. #AP7771c) in NCI-H460 cell line lysates (35ug/lane). NGFB (arrow) was detected using the purified Pab.
  • 14 - NGFB Antibody (Center) AP7771c
    Formalin-fixed and paraffin-embedded human brain tissue reacted with NGFB antibody (Center) (Cat.#AP7771c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • 4 - NGFB Antibody (Center) AP7771c
    NGFB Antibody (Center) (Cat. #AP7771c) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • 3 - NGFB Antibody (Center) AP7771c
    Confocal immunofluorescent analysis of NGFB Antibody (Center)(Cat#AP7771c) with MDA-MB231 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, FC, IF, E
Primary Accession P01138
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 26959 Da
Additional info
Gene ID 4803
Other Names Beta-nerve growth factor, Beta-NGF, NGF, NGFB
Target/Specificity This NGFB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-115 amino acids from the Central region of human NGFB.
Dilution WB~~1:1000
IHC-P~~1:10~50
FC~~1:10~50
IF~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNGFB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NGF
Synonyms NGFB
Function Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
Cellular Location Secreted.
Research Areas

BACKGROUND

NGFB is a member of the NGF-beta family. It is a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in the gene encoding NGFB have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of the gene's expression is associated with allergic rhinitis.

REFERENCES

Lang,U.E., Pharmacopsychiatry 41 (5), 196-199 (2008)
Truzzi,F., J. Invest. Dermatol. 128 (8), 2031-2040 (2008)
MacGrogan,D., J. Neurochem. 59 (4), 1381-1391 (1992)

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