|Application ||WB, E|
|Calculated MW||55735 Da|
|Other Names||Calcium/calmodulin-dependent protein kinase kinase 1, CaM-KK 1, CaM-kinase kinase 1, CaMKK 1, CaM-kinase IV kinase, Calcium/calmodulin-dependent protein kinase kinase alpha, CaM-KK alpha, CaM-kinase kinase alpha, CaMKK alpha, CAMKK1, CAMKKA|
|Target/Specificity||This CAMKK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-121 amino acids from the N-terminal region of human CAMKK1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CAMKK1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.|
|Cellular Location||Cytoplasm. Nucleus|
Provided below are standard protocols that you may find useful for product applications.
CAMKK1 belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade.
Guest,C.B., PLoS ONE 3 (2), E1606 (2008)
Rudd,M.F., Genome Res. 16 (6), 693-701 (2006)
Ishikawa,Y., FEBS Lett. 550 (1-3), 57-63 (2003)
Matsushita,M., J. Biol. Chem. 274 (15), 10086-10093 (1999)