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MYCN Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - MYCN Antibody (C-term) AP7395b
    Anti-MYCN Antibody (C-term) at 1:1000 dilution + CCRF-CEM whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 50 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 14 - MYCN Antibody (C-term) AP7395b
    Formalin-fixed and paraffin-embedded H.brain tissue reacted with MYCN Antibody (C-term) (Cat#AP7395b).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P04198
Other Accession Q63379, P03966
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 49561 Da
Additional info
Gene ID 4613
Other Names N-myc proto-oncogene protein, Class E basic helix-loop-helix protein 37, bHLHe37, MYCN, BHLHE37, NMYC
Target/Specificity This MYCN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-351 amino acids from the C-terminal region of human MYCN.
Dilution WB~~1:1000
IHC-P~~1:100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMYCN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYCN
Synonyms BHLHE37, NMYC
Function May function as a transcription factor.
Cellular Location Nucleus.
Research Areas
p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma.
Author : Li Z1, Sun Y2, Chen X1, Squires J1, Nowroozizadeh B1, Liang C3, Huang J2.
Mol Cancer Res. 2015 Mar;13(3):584-91. doi: 10.1158/1541-7786.MCR-14-0277-T. Epub 2014 Dec 15.
25512615

BACKGROUND

MYCN is a member of the MYC family and a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of its gene is associated with a variety of tumors, most notably neuroblastomas.

REFERENCES

Combaret,V., Pediatr Blood Cancer 53 (3), 329-331 (2009)
Alvarez-Rodriguez,R., J. Cell. Sci. 122 (PT 5), 595-599 (2009)
Jacobs,J.F., BMC Cancer 9, 239 (2009)

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