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MYCN Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - MYCN Antibody (C-term) AP7395b
    Anti-MYCN Antibody (C-term) at 1:1000 dilution + CCRF-CEM whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 50 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 14 - MYCN Antibody (C-term) AP7395b
    Formalin-fixed and paraffin-embedded H.brain tissue reacted with MYCN Antibody (C-term) (Cat#AP7395b).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P04198
Other Accession Q63379, P03966
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 49561 Da
Additional info
Gene ID 4613
Other Names N-myc proto-oncogene protein, Class E basic helix-loop-helix protein 37, bHLHe37, MYCN, BHLHE37, NMYC
Target/Specificity This MYCN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-351 amino acids from the C-terminal region of human MYCN.
Dilution WB~~1:1000
IHC-P~~1:100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMYCN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYCN
Synonyms BHLHE37, NMYC
Function Positively regulates the transcription of MYCNOS in neuroblastoma cells.
Cellular Location Nucleus.
Tissue Location Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level)
Research Areas
p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma.
Author : Li Z1, Sun Y2, Chen X1, Squires J1, Nowroozizadeh B1, Liang C3, Huang J2.
Mol Cancer Res. 2015 Mar;13(3):584-91. doi: 10.1158/1541-7786.MCR-14-0277-T. Epub 2014 Dec 15.
25512615

BACKGROUND

MYCN is a member of the MYC family and a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of its gene is associated with a variety of tumors, most notably neuroblastomas.

REFERENCES

Combaret,V., Pediatr Blood Cancer 53 (3), 329-331 (2009)
Alvarez-Rodriguez,R., J. Cell. Sci. 122 (PT 5), 595-599 (2009)
Jacobs,J.F., BMC Cancer 9, 239 (2009)

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