|Application ||WB, IHC-P, FC, E|
|Calculated MW||37496 Da|
|Other Names||Cathepsin S, CTSS|
|Target/Specificity||This CTSS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-240 amino acids from the Central region of human CTSS.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CTSS Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L.|
Provided below are standard protocols that you may find useful for product applications.
The protein CTSS, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The protein can function as an elastase over a broad pH range in alveolar macrophages.
Lindahl,C., Cancer Genomics Proteomics 6 (3), 149-159 (2009)
Bunatova,K., Int. J. Biol. Markers 24 (1), 47-51 (2009)