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CTSK Antibody (Center R222)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CTSK Antibody (Center R222) AP7381c
    Anti-CTSK Antibody (Center R222) at 1:2000 dilution + Mouse skeletal muscle lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 37 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 14 - CTSK Antibody (Center R222) AP7381c
    Formalin-fixed and paraffin-embedded human breast carcinoma with CTSK Antibody (Center R222), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • 4 - CTSK Antibody (Center R222) AP7381c
    Flow cytometric analysis of ZR-75-1 cells using CTSK Antibody (Center R222)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, FC, WB, E
Primary Accession P43235
Other Accession P43236, Q9GLE3, P61276, Q5E968
Reactivity Mouse
Predicted Bovine, Monkey, Pig, Rabbit
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 36966 Da
Additional info
Gene ID 1513
Other Names Cathepsin K, Cathepsin O, Cathepsin O2, Cathepsin X, CTSK, CTSO, CTSO2
Target/Specificity This CTSK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 207-237 amino acids from the Central region of human CTSK.
Dilution WB~~1:2000
IHC-P~~1:10~50
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCTSK Antibody (Center R222) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CTSK
Synonyms CTSO, CTSO2
Function Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
Cellular Location Lysosome.
Tissue Location Predominantly expressed in osteoclasts (bones)
Research Areas

BACKGROUND

The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing.

REFERENCES

Lendeckel,U., Neurochem. Int. 54 (7), 410-417 (2009)

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