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|Application ||WB, IHC-P, FC, E|
|Other Accession||Q3T1J9, Q921Y0|
|Calculated MW||25080 Da|
|Other Names||MOB kinase activator 1A, Mob1 alpha, Mob1A, Mob1 homolog 1B, Mps one binder kinase activator-like 1B, MOB1A, C2orf6, MOB4B, MOBK1B, MOBKL1B|
|Target/Specificity||This MOBKL1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-216 amino acids from the C-terminal region of human MOBKL1B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MOBKL1B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C2orf6, MOB4B, MOBK1B, MOBKL1B|
|Function||Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.|
|Tissue Location||Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver|
Author : Wilmeth LJ1, Shrestha S, Montaño G, Rashe J, Shuster CB.
Mol Biol Cell. 2010 Feb 1;21(3):380-92. doi: 10.1091/mbc.E09-06-0471. Epub 2009 Dec 2.
Provided below are standard protocols that you may find useful for product applications.
MOBKL1B stimulates the kinase activity of STK38 and STK38L.
Bichsel,S.J., J. Biol. Chem. 279 (34), 35228-35235 (2004)
Stavridi,E.S., Structure 11 (9), 1163-1170 (2003)