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>   首页   >   产品   >   一抗   >   癌症   >   CAMK2G (CAMK2 gamma) Antibody (C-term)   

CAMK2G (CAMK2 gamma) Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CAMK2G (CAMK2 gamma) Antibody (C-term) AP7208a
    Anti-CAMK2G (CAMK2 gamma) Antibody (C-term) at 1:500 dilution + T47D whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 61 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - CAMK2G (CAMK2 gamma) Antibody (C-term) AP7208a
    All lanes : Anti-CAMK2G (CAMK2 gamma) Antibody (C-term) at 1:500-1000 dilution Lane 1: Jurkat whole cell lysate Lane 2: U-251 MG whole cell lysate Lane 3: Human brain tissue lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 61 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - CAMK2G (CAMK2 gamma) Antibody (C-term) AP7208a
    Anti-CAMK2G (CAMK2 gamma) Antibody (C-term) at 1:2000 dilution + human liver lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 63kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - CAMK2G (CAMK2 gamma) Antibody (C-term) AP7208a
    The anti-CAMK2 gamma C-term Pab (Cat. #AP7208a) is used in Western blot to detect CAMK2 gamma in mouse heart tissue lysate.
  • 14 - CAMK2G (CAMK2 gamma) Antibody (C-term) AP7208a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q13555
Other Accession O15378
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 818
Other Names Calcium/calmodulin-dependent protein kinase type II subunit gamma, CaM kinase II subunit gamma, CaMK-II subunit gamma, CAMK2G, CAMK, CAMK-II, CAMKG
Target/Specificity This CAMK2G (CAMK2 gamma) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-338 amino acids from the C-terminal region of human CAMK2G (CAMK2 gamma).
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCAMK2G (CAMK2 gamma) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAMK2G
Synonyms CAMK, CAMK-II, CAMKG
Function Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow- twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.
Cellular Location Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side
Tissue Location Expressed in skeletal muscle.
Research Areas
Activation of CaMKIIγ potentiates T-cell acute lymphoblastic leukemia leukemogenesis via phosphorylating FOXO3a.
Author : Jiang X1,2,Wu Z1,2,Lu X1,2,Zhang X1,Yu Q1,2,Gan Y1,2,Wu B1,2,Xu Y1,2,Zheng W3,Zhang L1,2,Xu F2,Ma A4,Gan X4,Huang S5,Yu X2,Huang W6,7,Xu R1,2.
Oncotarget. 2017 Aug 24;8(43):75050-75064. doi: 10.18632/oncotarget.20504. eCollection 2017 Sep 26.
29088844

BACKGROUND

CaM-kinase II (CAMK2) is a prominent Ser/Thr protein kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Likely autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state. CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.

REFERENCES

Breen, M.A., et al., Biochem. Biophys. Res. Commun. 236(2):473-478 (1997). Tombes, R.M., et al., Biochim. Biophys. Acta 1355(3):281-292 (1997).

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