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AMHR2 Antibody (N-term R80)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - AMHR2 Antibody (N-term R80) AP7111b
    All lanes : Anti-AMHR2 Antibody (N-term) at 1:1000 dilution Lane 1: OVCAR3 whole cell lysate Lane 2: SK-OV-3 whole cell lysate Lane 3: MDA-MB-231 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 63 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q16671
Other Accession Q8K592
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 269
Other Names Anti-Muellerian hormone type-2 receptor, Anti-Muellerian hormone type II receptor, AMH type II receptor, MIS type II receptor, MISRII, MRII, AMHR2, AMHR, MISR2
Target/Specificity This AMHR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-91 amino acids from the N-terminal region of human AMHR2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAMHR2 Antibody (N-term R80) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AMHR2
Synonyms AMHR, MISR2
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas

BACKGROUND

The AMH receptor (AMHR or AMHR2) is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins. Anti-Mullerian hormone (AMH) and its receptor are involved in the regression of Mullerian ducts in male fetuses. Male sex differentiation is mediated by 2 discrete hormones produced by the fetal testis. Testosterone, produced by Leydig cells, virilizes the external genitalia and promotes prostatic growth; anti-Mullerian hormone (AMH) results in regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes.

REFERENCES

Picard, J.Y., et al., J. Soc. Biol. 196(3):217-221 (2002).
Teixeira, J., et al., Endocr. Rev. 22(5):657-674 (2001).
Imbeaud, S., et al., Nat. Genet. 11(4):382-388 (1995).
Visser, J.A., et al., Biochem. Biophys. Res. Commun. 215(3):1029-1036 (1995).
Sinisi, A.A., et al., J. Endocrinol. Invest. 26 (3 Suppl), 23-28 (2003).

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