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Drosophila Parkin Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Drosophila Parkin Antibody (N-term) AP6414a
    The anti-Drosophila Parkin Pab (Cat. #AP6414a) is used in Western blot to detect Drosophila Parkin in, from left to right, mouse kidney, mouse brain, mouse heart, Ramos, and Hela tissue lysates.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q7KTX7
Reactivity Drosophila
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 40336
Other Names CG10523-PB; isoform B; Cg10523-pc; isoform c; PARKIN; park; parkin;
Target/Specificity This Drosophila Parkin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-111 amino acids from the N-terminal region of human Drosophila Parkin.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDrosophila Parkin Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Q7KTX7
Function Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
Research Areas

BACKGROUND

Parkin is thought to play a role in the ubiquitin/proteasome pathway for protein degradation. The amino terminus bears sequence homology to ubiquitin while functionally it acts as a RING-type ubiquitin protein ligase (E3) that coordinates the transfer of ubiquitin to substrate proteins, thus targeting them for degradation by the proteasome. Mutations in the human version of the protein are known to cause autosomal recessive juvenile parkinsonism.

REFERENCES

Zhong,L. et al. J. Biol. Chem. 280 (10), 9425-9430 (2005)
Pesah,Y. et al. Development 131 (9), 2183-2194 (2004)
Haywood,A.F. et al. BMC Neurosci 5, 14 (2004)
Finney,N. et al. J. Biol. Chem. 278 (18), 16054-16058 (2003)
Yang,Y. et al. Neuron 37 (6), 911-924 (2003)

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