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DSCR1 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - DSCR1 Antibody (C-term) AP6315c
    Endothelial cell lysate transferred to membrane was incubated with primary antibody at a 1:500 dilution in 2% BSA in TBST at 4deg C overnight. Data courtesy of Dr. Katherine Healey, NWCRF Institute, School of Biological Sciences, University of Wales Bangor.
  • 1 - DSCR1 Antibody (C-term) AP6315c
    The anti-DSCR1 Pab (Cat. #AP6315c) is used in Western blot to detect DSCR1 in endothelial tissue lysate.
  • 产品详情
  • 文献引用 : 8
  • 实验流程
  • 背景知识
Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P53805
Other Accession Q6IN33, Q9JHG6, O35847, Q3ZBP4, Q7Z555
Reactivity Human
Predicted Mouse, Rat, Hamster, Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 1827
Other Names Calcipressin-1, Adapt78, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Regulator of calcineurin 1, RCAN1, ADAPT78, CSP1, DSC1, DSCR1
Target/Specificity This DSCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-252 amino acids from the C-terminal region of human DSCR1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDSCR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RCAN1
Synonyms ADAPT78, CSP1, DSC1, DSCR1
Function Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity).
Tissue Location Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues
Research Areas
RCAN1 deficiency protects against Salmonella intestinal infection by modulating JNK activation.
Author : Lei QQ1, Hu GQ1, Chen W1, Yu SX1, Qi S1, Du CT1, Gu JM1, Lin TJ2, Yang YJ3.
Mol Immunol. 2016 Jul 21;77:26-33. doi: 10.1016/j.molimm.2016.07.009. [Epub ahead of print]
27449908
DSCR1 is required for both axonal growth cone extension and steering.
Author : Wang W1, Rai A1, Hur EM2, Smilansky Z3, Chang KT4, Min KT5.
J Cell Biol. 2016 May 16. pii: jcb.201510107. [Epub ahead of print]
27185837
Ubiquitin-specific Protease 22 (USP22) Positively Regulates RCAN1 Protein Levels through RCAN1 De-ubiquitination.
Author : Hong A1, Lee JE, Chung KC.
J Cell Physiol. 2014 Dec 24. doi: 10.1002/jcp.24917. [Epub ahead of print]
25546086
NGF upregulates the plasminogen activation inhibitor-1 in neurons via the Calcineurin/NFAT pathway and the down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect.
Author : Stefos GC, Soppa U, Dierssen M, Becker W.
PLoS One. 2013 Jun 25;8(6):e67470. doi: 10.1371/journal.pone.0067470. Print 2013.
23825664
Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections.
Author : Junkins RD1, MacNeil AJ, Wu Z, McCormick C, Lin TJ.
J Immunol. 2013 May 15;190(10):5178-86. doi: 10.4049/jimmunol.1203196. Epub 2013 Apr 15.
23589609
DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis.
Author : Wang W1, Zhu JZ, Chang KT, Min KT.
EMBO J. 2012 Sep 12;31(18):3655-66. doi: 10.1038/emboj.2012.190. Epub 2012 Aug 3.
22863780
Glucocorticoid evoked upregulation of RCAN1-1 in human leukemic CEM cells susceptible to apoptosis.
Author : Hirakawa Y, Nary LJ, Medh RD.
J Mol Signal. 2009 Sep 2;4:6. doi: 10.1186/1750-2187-4-6.
19725972
Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function.
Author : Yang YJ, Chen W, Edgar A, Li B, Molkentin JD, Berman JN, Lin TJ.
J Exp Med. 2009 Jan 16;206(1):195-207. doi: 10.1084/jem.20081140. Epub 2009 Jan 5.
19124655

BACKGROUND

DSCR1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. The gene for this protein is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of DSCR1 may lead to neurofibrillary tangles such as those associated with Alzheimer disease.

REFERENCES

Minami, T., et al., J. Biol. Chem. 279(48):50537-50554 (2004). Yao, Y.G., et al., Biochem. Biophys. Res. Commun. 321(3):648-656 (2004). Michtalik, H.J., et al., Free Radic. Biol. Med. 37(4):454-462 (2004). Hesser, B.A., et al., Blood 104(1):149-158 (2004). Iizuka, M., et al., Biochem. Biophys. Res. Commun. 41(4):334-344 (2004).

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