- 文献引用 : 1
|Application ||WB, IHC-P, FC, E|
|Calculated MW||112211 Da|
|Other Names||Microtubule-associated protein 1S, MAP-1S, BPY2-interacting protein 1, Microtubule-associated protein 8, Variable charge Y chromosome 2-interacting protein 1, VCY2-interacting protein 1, VCY2IP-1, MAP1S heavy chain, MAP1S light chain, MAP1S, BPY2IP1, C19orf5, MAP8, VCY2IP1|
|Target/Specificity||This MAP1S antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-520 amino acids from the Central region of human MAP1S.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAP1S Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BPY2IP1, C19orf5, MAP8, VCY2IP1|
|Function||Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).|
|Cellular Location||Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Detected in filopodia-like protrusions and synapses (By similarity). Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1 isoform A. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules.|
|Tissue Location||Expressed in neurons (at protein level). Expressed in spermatocytes, spermatids and spermatozoa. Expressed in the cerebral cortex. Highly expressed in testis. Moderately expressed in the brain, colon, heart, kidney, liver, lung, placenta, small intestine, spleen and stomach. Weakly expressed in muscle.|
Author : Bai W1,Bai J2,Li Y3,Tian D3,Shi R4.
Biochem Biophys Res Commun. 2017 Feb 7. pii: S0006-291X(17)30302-9. doi: 10.1016/j.bbrc.2017.02.034. [Epub ahead of print]
Provided below are standard protocols that you may find useful for product applications.
Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule-organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Wong, E.Y., et al. Biol. Reprod. 70(3):775-784(2004)
Liu, L., et al. In Vitro Cell. Dev. Biol. Anim. 38(10):582-594(2002)
Liu, L., et al. Genomics 79(1):124-136(2002)