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>   首页   >   产品   >   一抗   >   精选抗体   >   Anti-Cytokeratin 18 Mouse mAb   

Anti-Cytokeratin 18 Mouse mAb

Purified Mouse Monoclonal Antibody (Mab)

     
  • 2 - Anti-Cytokeratin 18 Mouse mAb AP53488
    Immunohistochemical analysis of KRT18 in Human appendix tissue sections(IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde at room temperature; antigen retrieval was by heat mediation with a EDTA buffer (pH9.0). Samples were incubated with primary antibody (1/400) for 1 hours at room temperature. A undiluted biotinylated CRF Anti-Polyvalent HRP Polymer antibody was used as the secondary antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession P05783
Reactivity Human
Host Mouse
Clonality Monclonal Antibody
Isotype Mouse IgG2b
Immunogen Purified recombinant fragment of human Cytokeratin 18 (aa391-483) expressed in E. Coli.
Purification Acites
Calculated MW 48kDa KDa
Antigen Region aa391-483
Additional Information
Gene ID 3875
Other Names CK18; CYK18; KRT18
Dilution IHC~~1:400
Format Ascitic fluid containing 0.03% sodium azide.
Storage Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Protein Information
Name KRT18
Synonyms CYK18
Function Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Cellular Location Cytoplasm, perinuclear region. Nucleus, nucleolus
Tissue Location Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
Research Areas

BACKGROUND

Cytokeratin 18, also known as CK18, CYK18, KRT18. Entrez Protein NP_000215. It encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.

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