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Anti-Met Antibody

Mouse Monoclonal Antibody

     
  • 1 - Anti-Met Antibody AP53480
    Western blot detection of Met in CHO-K1(B) and CHO-K1 transfected by Met-fragment EGFP fusion protein(A)cell lysates using Met mouse mAb (1:1000 diluted).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P08581
Other Accession NM_000245
Host Mouse
Clonality Monoclonal
Isotype lgG2a
Immunogen Purified recombinant human Met protein expressed in E.coli.
Purification Affinity purified
Calculated MW 156KDa KDa
Additional Information
Gene ID 4233
Other Names AUTS9;c met;D249;Hepatocyte growth factor receptor;HGF;HGF receptor;HGF/SF receptor;HGFR;MET;Met proto oncogene tyrosine kinase;MET proto oncogene, receptor tyrosine kinase;Met proto-oncogene (hepatocyte growth factor receptor);Met proto-oncogene;Met protooncogene;MET_HUMAN;Oncogene MET;Par4;Proto-oncogene c-Met;RCCP2;Scatter factor receptor;SF receptor;Tyrosine-protein kinase Met.
Dilution WB~~1:1000
Format Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name MET
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also present in the brain
Research Areas

BACKGROUND

Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival.

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