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Anti-Toll-like Receptor 3 Antibody

Mouse Monoclonal Antibody

     
  • 1 - Anti-Toll-like Receptor 3 Antibody AP53439
    Western blot detection of Toll-like Receptor 7 in CHO-K1 cell lysate(B)and CHO-K1 transfected by Toll-like Receptor 3(A)cell lysate using Toll-like Receptor 3 mouse mAb (1:1000 diluted).Predicted band size: 50KDa.Observed band size:50KDa.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession O15455
Other Accession NM_003265
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Immunogen Purified recombinant human Toll-Like Receptor 3 protein fragments expressed in E.coli.
Purification Affinity purified
Additional Information
Gene ID 7098
Other Names CD283 ; CD283 antigen ; IIAE2 ; TLR 3 ; Tlr3 ; TLR3_HUMAN ; Toll Like Receptor 3 ; Toll-like receptor 3.
Dilution WB~~1:1000
Format Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name TLR3
Function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
Cellular Location Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane
Tissue Location Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons.
Research Areas

BACKGROUND

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-st

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