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Anti-HtrA2/Omi Antibody

Mouse Anti Human Monoclonal Antibody

     
  • 1 - Anti-HtrA2/Omi Antibody AP53417
    Western blot detection of HtrA2/Omi in CHO-K1,MEF and 3T3 cell lysates using HtrA2/Omi mouse mAb(dilution 1:1000).Predicted band size:49kDa.Observed band size:36kDa.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession O43464
Other Accession NM_013247
Reactivity Mouse, Hamster
Host Mouse
Clonality Monoclonal
Isotype IgG1
Immunogen Recombinant human HtrA2/Omi protein.
Purification Affinity purified
Calculated MW 36 KDa
Additional Information
Gene ID 27429
Other Names High temperature requirement protein A2;HTRA 2;HtrA like serine protease;HtrA serine peptidase 2;HtrA, E. coli, homolog of, 2;HtrA2;HTRA2_HUMAN;mitochondrial;Omi stress regulated endoprotease;Omi stress-regulated endoprotease;PARK 13;PARK13;Protease serine 25;PRSS 25;PRSS25;Serine protease 25;Serine protease HTRA2;Serine protease HTRA2 mitochondrial;Serine protease htra2 mitochondrial precursor;Serine protease omi;Serine proteinase OMI.
Dilution WB~~1:1000
Format PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name HTRA2
Synonyms OMI, PRSS25
Function Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
Cellular Location Mitochondrion intermembrane space. Mitochondrion membrane; Single-pass membrane protein. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID
Tissue Location Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid
Research Areas

BACKGROUND

Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an inc

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