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Anti-SIRT6 Antibody

Mouse Anti Human Monoclonal Antibody

     
  • 1 - Anti-SIRT6 Antibody AP53392
    Western blot analysis of extracts from Jurkat,MCF7,HCT116,K562,COS7,C2C12,3T3 and Hela cell lysates using SIRT6 mouse mAb (1:500 diluted).Predicted band size:42,36KDa.Observed band size:42,36KDa.
  • 8 - Anti-SIRT6 Antibody AP53392
    Immunofluorescent analysis of Hela cells fixed fixed by 4% paraformaldehyde and using SIRT6 mouse mAb (dilution 1:100).
  • 5 - Anti-SIRT6 Antibody AP53392
    Immunoprecipitation analysis of Hela cell lysates using SIRT6 mouse mAb.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF, IP
Primary Accession Q8N6T7
Other Accession NM_016539
Reactivity Human, Mouse, Rat, Monkey
Host Mouse
Clonality Monoclonal
Isotype IgG1
Immunogen Purified recombinant human SIRT6 protein expressed in E.coli.
Purification Affinity purified
Calculated MW 42 KDa
Additional Information
Gene ID 51548
Other Names 2810449N18Rik;AI043036;Mono ADP ribosyltransferase sirtuin 6;NAD-dependent protein deacetylase sirtuin-6;Regulatory protein SIR2 homolog 6;Regulatory protein SIR2 homolog;SIR2 like 6;SIR2 like protein 6;Sir2 related protein type 6;SIR2-like protein 6;SIR2
Dilution WB~~1:500
ICC~~1:100
Format PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name SIRT6
Synonyms SIR2L6
Function NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
Cellular Location Nucleus, nucleoplasm. Note=Predominantly nuclear Associated with telomeric heterochromatin regions
Research Areas

BACKGROUND

NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and

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