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PABPC5 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - PABPC5 Antibody AP53359
    All lanes : Anti-PABPC5 Antibody at 1:1000 dilution Lane 1: Hela whole cell lysate Lane 2: A431 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution. Predicted band size : 43 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q96DU9
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 43 KDa
Additional info
Other Names Polyadenylate-binding protein 5, PABP-5, Poly(A)-binding protein 5, PABPC5, PABP5
Dilution WB~~ 1:1000
Format Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name PABPC5
Synonyms PABP5
Function Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).
Cellular Location Cytoplasm.
Tissue Location Expressed in fetal brain and in a range of adult tissues EMBL; AJ278963; CAC42826.1; -; Genomic_DNA EMBL; AK290105; BAF82794.1; -; mRNA EMBL; AL662874; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471115; EAX02776.1; -; Genomic_DNA EMBL; BC063113; AAH63113.1; -; mRNA EMBL; AL122118; CAB59276.1; -; mRNA CCDS; CCDS14460.1; -. [Q96DU9-1] PIR; T34543; T34543 RefSeq; NP_543022.1; NM_080832.2. [Q96DU9-1] UniGene; Hs.246590; - ProteinModelPortal; Q96DU9; - SMR; Q96DU9; - BioGrid; 126753; 4 IntAct; Q96DU9; 3 STRING; 9606.ENSP00000308012; - iPTMnet; Q96DU9; - PhosphoSitePlus; Q96DU9; - BioMuta; PABPC5; - DMDM; 28201851; - EPD; Q96DU9; - jPOST; Q96DU9; - MaxQB; Q96DU9; - PaxDb; Q96DU9; - PeptideAtlas; Q96DU9; - PRIDE; Q96DU9; - ProteomicsDB; 76329; - DNASU; 140886; - Ensembl; ENST00000312600; ENSP00000308012; ENSG00000174740. [Q96DU9-1] GeneID; 140886; - KEGG; hsa:140886; - UCSC; uc004efg.4; human. [Q96DU9-1] CTD; 140886; - EuPathDB; HostDB:ENSG00000174740.7; - GeneCards; PABPC5; - HGNC; HGNC:13629; PABPC5 HPA; HPA000164; - HPA; HPA000165; - MIM; 300407; gene neXtProt; NX_Q96DU9; - OpenTargets; ENSG00000174740; - PharmGKB; PA32884; - eggNOG; KOG0123; Eukaryota eggNOG; ENOG410XR5X; LUCA GeneTree; ENSGT00940000162668; - HOGENOM; HOG000217922; - HOVERGEN; HBG002295; - InParanoid; Q96DU9; - KO; K13126; - OMA; MVEVGQG; - OrthoDB; 1027234at2759; - PhylomeDB; Q96DU9; - TreeFam; TF300458; - GenomeRNAi; 140886; - PRO; PR:Q96DU9; - Proteomes; UP000005640; Chromosome X Bgee; ENSG00000174740; Expressed in 96 organ(s), highest expression level in adrenal tissue ExpressionAtlas; Q96DU9; baseline and differential Genevisible; Q96DU9; HS GO; GO:0005737; C:cytoplasm; IBA:GO_Central GO; GO:0010494; C:cytoplasmic stress granule; IBA:GO_Central GO; GO:0005829; C:cytosol; IBA:GO_Central GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell GO; GO:0005634; C:nucleus; IBA:GO_Central GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central GO; GO:0008143; F:poly(A) binding; IBA:GO_Central GO; GO:0008266; F:poly(U) RNA binding; IBA:GO_Central GO; GO:0003723; F:RNA binding; IBA:GO_Central Gene3D; 3.30.70.330; -; 4 InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf InterPro; IPR006515; PABP_1234 InterPro; IPR035979; RBD_domain_sf InterPro; IPR000504; RRM_dom InterPro; IPR003954; RRM_dom_euk Pfam; PF00076; RRM_1; 4 SMART; SM00360; RRM; 4 SMART; SM00361; RRM_1; 3 SUPFAM; SSF54928; SSF54928; 2 TIGRFAMs; TIGR01628; PABP-1234; 1 PROSITE; PS50102; RRM; 4 2: Evidence at transcript level; Alternative initiation; Complete proteome; Cytoplasm; Mitochondrion; Polymorphism; Reference proteome; Repeat; RNA-binding CHAIN 1 382 Polyadenylate-binding protein 5 /FTId=PRO_0000081705 DOMAIN 18 96 RRM 1. {ECO:0000255|PROSITE- ProRule:PRU00176} DOMAIN 106 182 RRM 2. {ECO:0000255|PROSITE- ProRule:PRU00176} DOMAIN 199 276 RRM 3. {ECO:0000255|PROSITE- ProRule:PRU00176} DOMAIN 302 378 RRM 4. {ECO:0000255|PROSITE- ProRule:PRU00176} VAR_SEQ 1 32 Missing (in isoform 2). /FTId=VSP_047456 VARIANT 314 314 N -> S (in dbSNP:rs7050077) /FTId=VAR_054049 SEQUENCE 382 AA; 43331 MW; 23B34751780C602B CRC64; MGSGEPNPAG KKKKYLKAAL YVGDLDPDVT EDMLYKKFRP AGPLRFTRIC RDPVTRSPLG YGYVNFRFPA DAEWALNTMN FDLINGKPFR LMWSQPDDRL RKSGVGNIFI KNLDKSIDNR ALFYLFSAFG NILSCKVVCD DNGSKGYAYV HFDSLAAANR AIWHMNGVRL NNRQVYVGRF KFPEERAAEV RTRDRATFTN VFVKNIGDDI DDEKLKELFC EYGPTESVKV IRDASGKSKG FGFVRYETHE AAQKAVLDLH GKSIDGKVLY VGRAQKKIER LAELRRRFER LRLKEKSRPP GVPIYIKNLD ETINDEKLKE EFSSFGSISR AKVMMEVGQG KGFGVVCFSS FEEATKAVDE MNGRIVGSKP LHVTLGQARR RC
Research Areas

BACKGROUND

Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).

REFERENCES

Blanco P.,et al.Genomics 74:1-11(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ross M.T.,et al.Nature 434:325-337(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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