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LONP2 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - LONP2 Antibody AP53352
    Anti-LONP2 Antibody at 1:1000 dilution + K562 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution. Predicted band size : 95 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q86WA8
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 95 KDa
Additional info
Gene ID 83752
Other Names Lon protease homolog 2, peroxisomal {ECO:0000255|HAMAP-Rule:MF_03121}, 3.4.21.- {ECO:0000255|HAMAP-Rule:MF_03121}, Lon protease-like protein 2 {ECO:0000255|HAMAP-Rule:MF_03121}, Lon protease 2 {ECO:0000255|HAMAP-Rule:MF_03121}, Peroxisomal Lon protease {ECO:0000255|HAMAP-Rule:MF_03121}, LONP2 {ECO:0000255|HAMAP-Rule:MF_03121}, LONP
Dilution WB~~ 1:1000
Format Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name LONP2 {ECO:0000255|HAMAP-Rule:MF_03121}
Synonyms LONP
Function ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.
Cellular Location Peroxisome matrix {ECO:0000255|HAMAP- Rule:MF_03121, ECO:0000269|PubMed:14561759, ECO:0000269|PubMed:18281296, ECO:0000269|PubMed:22002062}
Tissue Location Widely expressed, with high levels in the liver, kidney and pancreas.
Research Areas

BACKGROUND

ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.

REFERENCES

De Walque S.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Kikuchi M.,et al.J. Biol. Chem. 279:421-428(2004).

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