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>   首页   >   产品   >   一抗   >   癌症   >   HER3 (pY1222) Antibody   

HER3 (pY1222) Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - HER3 (pY1222) Antibody AP53346
    Anti-HER3 (pY1222) Antibody at 1:1000 dilution + SK-BR-3 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution. Predicted band size : 148 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P21860
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 140 KDa
Additional info
Gene ID 2065
Other Names Receptor tyrosine-protein kinase erbB-3, 2.7.10.1, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, ERBB3, HER3
Dilution WB~~ 1:1000
Format Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name ERBB3
Synonyms HER3
Function Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134).
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location Epithelial tissues and brain.
Research Areas

BACKGROUND

Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.

REFERENCES

Kraus M.H.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:9193-9197(1989).
Plowman G.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:4905-4909(1990).
Katoh M.,et al.Biochem. Biophys. Res. Commun. 192:1189-1197(1993).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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