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>   首页   >   产品   >   一抗   >   癌症   >   DOK1 Antibody   

DOK1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - DOK1 Antibody AP53342
    All lanes : Anti-DOK1 Antibody at 1:1000 dilution Lane 1: K562 whole cell lysate Lane 2: Jurkat whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution. Predicted band size : 52 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q99704
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 52 KDa
Additional info
Gene ID 1796
Other Names Docking protein 1, Downstream of tyrosine kinase 1, p62(dok), pp62, DOK1
Dilution WB~~ 1:1000
Format Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name DOK1
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Cellular Location Isoform 1: Cytoplasm. Nucleus.
Tissue Location Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer
Research Areas

BACKGROUND

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

REFERENCES

Carpino N.,et al.Cell 88:197-204(1997).
Hubert P.,et al.Eur. J. Immunogenet. 27:145-148(2000).
Yu W.,et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Wick M.J.,et al.J. Biol. Chem. 276:42843-42850(2001).

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