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>   首页   >   产品   >   一抗   >   癌症   >   Cytochrome P450 2W1 Antibody   

Cytochrome P450 2W1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Cytochrome P450 2W1 Antibody AP53339
    Anti-Cytochrome P450 2W1 Antibody at 1:1000 dilution + HepG2 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution. Predicted band size : 54 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q8TAV3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 54 KDa
Additional info
Gene ID 54905
Other Names Cytochrome P450 2W1, 1.14.14.-, CYPIIW1, CYP2W1
Dilution WB~~ 1:1000
Format Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name CYP2W1
Function Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:16551781, PubMed:24278521). Actives also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products (PubMed:20805301). Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids (PubMed:22591743).
Cellular Location Endoplasmic reticulum lumen. Cell membrane. Note=About 8% are expressed on the cell surface.
Tissue Location Very low levels are detected in fetal and adult tissues. Highly expressed in several tumor samples, in particular colon and adrenal tumors
Research Areas

BACKGROUND

Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:16551781, PubMed:24278521). Actives also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products (PubMed:20805301). Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids (PubMed:22591743).

REFERENCES

Hillier L.W.,et al.Nature 424:157-164(2003).
Karlgren M.,et al.Biochem. Biophys. Res. Commun. 341:451-458(2006).
Wu Z.L.,et al.Mol. Pharmacol. 69:2007-2014(2006).
Gomez A.,et al.Mol. Pharmacol. 78:1004-1011(2010).
Eun C.Y.,et al.Toxicol. Res. 26:171-175(2010).

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