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SCN4B Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - SCN4B Antibody AP53322
    Anti-SCN4B Antibody at 1:1000 dilution + human brain lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution. Predicted band size : 25 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q8IWT1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 25 KDa
Additional info
Gene ID 6330
Other Names Sodium channel subunit beta-4, SCN4B
Dilution WB~~ 1:1000
Format Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name SCN4B
Function Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium.
Research Areas

BACKGROUND

Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.

REFERENCES

Yu F.H.,et al.J. Neurosci. 23:7577-7585(2003).
Taylor T.D.,et al.Nature 440:497-500(2006).
Gilchrist J.,et al.Proc. Natl. Acad. Sci. U.S.A. 110:E5016-E5024(2013).
Medeiros-Domingo A.,et al.Circulation 116:134-142(2007).
Olesen M.S.,et al.Cardiovasc. Res. 89:786-793(2011).

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