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HP1-gamma Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - HP1-gamma Antibody AP53280
    Western blot detection of HP1-gamma in Hela,3T3,C6,COS7 and CHO-K1 cell lysates using HP1-gamma mouse mAb (1:1000 diluted).Predicted band size:22KDa.Observed band size:22KDa.
  • 8 - HP1-gamma Antibody AP53280
    Immunocytochemistry staining of HeLa cells fixed with 4% Paraformaldehyde and using anti-HP1-gamma mouse mAb (dilution 1:200).
  • 5 - HP1-gamma Antibody AP53280
    Immunoprecipitation analysis of Hela cell lysates using HP1-gamma mouse mAb.
  • 2 - HP1-gamma Antibody AP53280
    Immunohistochemical analysis of paraffin-embedded Prostate Cancer using HP1-gamma mouse mAb (1/200 dilution).Antigen retrieval was performed by pressure cooking in citrate buffer (pH 6.0).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, ICC, IP, IHC
Primary Accession Q13185
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 22 KDa
Additional Information
Gene ID 11335
Other Names CBX 3;CBX3 ;CBX3_HUMAN;Chromobox homolog 3 (HP1 gamma homolog, Drosophila);Chromobox homolog 3;Chromobox protein homolog 3 ;GAMMA; HECH;Heterochromatin like protein 1; Heterochromatin protein 1 homolog gamma;Heterochromatin protein HP1 gamma;HP1 gamma;HP1 gamma homolog;HP1Hs gamma;Modifier 2 protein.
Dilution WB~~1:1000
ICC~~1:200
IP~~1:500
IHC~~1:100
Format Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name CBX3
Function Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the mehtyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.
Cellular Location Nucleus. Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential).
Research Areas

BACKGROUND

Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the mehtyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.

REFERENCES

Ye Q.,et al.J. Biol. Chem. 271:14653-14656(1996).
Ye Q.,et al.Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
Koike N.,et al.FEBS Lett. 467:17-21(2000).
Chen J.H.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Lubec G.,et al.Submitted (MAR-2007) to UniProtKB.

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