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E2F-1 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - E2F-1 Antibody AP52849
    Western blot detection of E2F-1 in C6,Raw264.7 and Hela cell lysates using E2F-1 mouse mAb (1:500 diluted).Predicted band size:70KDa.Observed band size:70KDa.
  • 8 - E2F-1 Antibody AP52849
    Immunofluorescent analysis of Hela cells fixed with 4% Paraformaldehyde and using anti-E2F-1 mouse mAb (dilution 1:100). DAPI was used to stain nucleus(blue).
  • 5 - E2F-1 Antibody AP52849
    Immunoprecipitation analysis of Hela cell lysates using E2F-1 mouse mAb.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, ICC, IP
Primary Accession Q01094
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Calculated MW 70 KDa
Additional Information
Gene ID 1869
Other Names Dmel\CG6376 ; Dmel_CG6376 ; drosE2F1 ; E(Sev-CycE)3A ; E(var)3-93E ; E2-promoter binding facto ; E2F 1 ; E2F transcription factor 1 ; E2F-1 ; E2f-PA ; E2f-PB ; E2f-PC ; E2F1 ; E2f1 E2F transcription factor 1 ; E2F1_HUMAN ; Evar(3)164 ; KIAA4009 ; l(3)07172 ; l(3)j3B1 ; l(3)j3C2 ; l(3)rM729 ; mKIAA4009 ; OTTHUMP00000030661 ; PBR3 ; PRB binding protein E2F 1 ; PRB-binding protein E2F-1 ; RBAP 1 ; RBAP-1 ; RBAP1 ; RBBP-3 ; RBBP3 ; RBP 3 ; RBP3 ; Retinoblastoma-associated protein 1 ; Retinoblastoma-binding protein 3 ; Transcription factor E2F1.
Dilution WB~~1:500
ICC~~1:100
IP~~1:500
Format Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name E2F1
Synonyms RBBP3
Function Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis.
Cellular Location Nucleus.
Research Areas

BACKGROUND

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis.

REFERENCES

Helin K.,et al.Cell 70:337-350(1992).
Kaelin W.G. Jr.,et al.Cell 70:351-364(1992).
Shan B.,et al.Mol. Cell. Biol. 12:5620-5631(1992).
Neuman E.,et al.Gene 173:163-169(1996).
Deloukas P.,et al.Nature 414:865-871(2001).

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