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ERCC1 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - ERCC1 Antibody AP52840
    Western blot detection of ERCC1 in T47D,ZR75-1,CaCO2 and Molt-4 cell lysate using ERCC1 mouse mAb (1:1000 diluted).Predicted band size: 39KDa.Observed band size: 39KDa.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P07992
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Calculated MW 39 KDa
Additional Information
Gene ID 2067
Other Names COFS 4;COFS4;DNA excision repair protein ERCC 1;DNA excision repair protein ERCC-1;DNA excision repair protein ERCC1;ERCC 1;ERCC1;ERCC1_HUMAN;Excision repair cross complementing 1;Excision Repair Cross Complementing Rodent Repair Deficiency Complementation Group 1;Excision repair protein;RAD 10;RAD10;UV 20;UV20.
Dilution WB~~1:1000
Format Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide,0.1mg/mlBSA and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name ERCC1
Function Isoform 1: Non-catalytic component of a structure- specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.
Cellular Location Isoform 1: Nucleus. Isoform 3: Nucleus.
Research Areas

BACKGROUND

Isoform 1: Non-catalytic component of a structure- specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.

REFERENCES

van Duin M.,et al.Cell 44:913-923(1986).
Hoeijmakers J.H.J.,et al.Cold Spring Harb. Symp. Quant. Biol. 51:91-101(1986).
Yu J.J.,et al.Mutat. Res. 382:13-20(1997).
Hisatomi H.,et al.Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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