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XRCC1 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - XRCC1 Antibody AP52839
    Western blot detection of XRCC1 in Raji,K562,Hela,Jurkat and THP-1 cell lysates using XRCC1 mouse mAb (1:1000 diluted).Predicted band size:82KDa.Observed band size:82KDa.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P18887
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 82 KDa
Additional Information
Gene ID 7515
Other Names DNA repair protein XRCC1;RCC;X ray repair complementing defective repair in chinese hamster;X ray repair complementing defective repair in chinese hamster cells 1;X ray Repair Complementing Defective Repair in Chinese Hamster Cells;X ray repair cross complementing protein 1;X ray repair, complementing defective, repair in Chinese hamster;X-ray repair cross-complementing protein 1;XRCC 1;Xrcc1;XRCC1_HUMAN.
Dilution WB~~1:1000
Format Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name XRCC1
Function Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity.
Cellular Location Nucleus. Note=Moves from the nucleoli to the global nuclear chromatin upon DNA damage
Tissue Location Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level)
Research Areas

BACKGROUND

Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.

REFERENCES

Thompson L.H.,et al.Mol. Cell. Biol. 10:6160-6171(1990).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
Whitehouse C.J.,et al.Cell 104:107-117(2001).
Sano Y.,et al.Ann. Neurol. 55:241-249(2004).

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