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Lamin A Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - Lamin A Antibody AP52832
    Western blot detection of Lamin A in K562,C6,3T3 and Hela cell lysates using Lamin A mouse mAb (1:1000 diluted).Predicted band size:74KDa.Observed band size:74KDa.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P02545
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Calculated MW 74 KDa
Additional Information
Gene ID 4000
Other Names 70 kDa lamin ; CDCD1 ; CDDC ; CMD1A ; CMT2B1 ; EMD2 ; FPL ; FPLD ; HGPS ; IDC ; LAMIN A ; lamin A/C ; LAMIN C ; Lamin-A/C ; LDP1 ; LFP ; LGMD1B ; LMN 1 ; LMN A ; LMN C ; LMN1 ; LMNA ; LMNA_HUMAN ; LMNC ; NY REN 32 antigen ; PRO1 ; Renal carcinoma antigen NY-REN-32
Dilution WB~~1:1000
Format 0.03% Proclin300 and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name LMNA
Synonyms LMN1
Function Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone.
Cellular Location Nucleus. Nucleus envelope. Nucleus lamina. Nucleus, nucleoplasm. Note=Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin- A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C
Tissue Location In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.
Research Areas

BACKGROUND

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone.

REFERENCES

McKeon F.D.,et al.Nature 319:463-468(1986).
Fisher D.Z.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:6450-6454(1986).
Sylvius N.,et al.J. Med. Genet. 42:639-647(2005).
Csoka A.B.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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