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Hsp90 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - Hsp90 Antibody AP52820
    Western blot detection of Hsp90 in Hela,3T3,C6,K562 and A549 cell lysates using Hsp90 mouse mAb (1:2000 diluted).Exposion time: 4min.Predicted band size:90KDa.Observed band size:90KDa.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P07900
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 90 KDa
Additional Information
Gene ID 3320
Other Names D6S182;FLJ26984;FLJ31884;Heat shock 86 kDa;heat shock 90kDa protein 1 alpha;Heat shock protein 90kDa alpha cytosolic class A member 1;Heat shock protein 90kDa alpha cytosolic class B member 1; Heat shock protein HSP 90 alpha;Heat shock protein HSP 90 beta;Heat shock protein HSP 90-alpha;HS90A_HUMAN;HSP 84;HSP 86;Hsp 90;HSP84;HSP86;Hsp89;Hsp90;HSP90 Beta;HSP90A;HSP90AA1;HSP90AB1;HSP90B;HSP90N;HSPC1;HSPC2;HSPCA;HSPCAL1;HSPCAL4;HSPCB;HSPN;LAP2;Lipopolysaccharide associated protein2;LPS associated protein 2;NY REN 38 antigen;Renal carcinoma antigen NY-REN-38.
Dilution WB~~1:2000
Format Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name HSP90AA1
Synonyms HSP90A, HSPC1, HSPCA
Function Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
Cellular Location Cytoplasm. Melanosome. Cell membrane. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Research Areas

BACKGROUND

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

REFERENCES

Soeda E.,et al.Nucleic Acids Res. 17:7108-7108(1989).
Yamazaki M.,et al.Agric. Biol. Chem. 54:3163-3170(1990).
Hickey E.,et al.Mol. Cell. Biol. 9:2615-2626(1989).
Chen B.,et al.Genomics 86:627-637(2005).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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