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OLIG2 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - OLIG2 Antibody AP52803
    Western blot detection of OLIG2 in CHO-K1 cell lysate(B)and CHO-K1 transfected by EGFP-OLIG2 fragment(A)cell lysate using OLIG2 mouse mAb (1:1000 diluted).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q13516
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 32 KDa
Additional Information
Gene ID 10215
Other Names Basic domain helix loop helix protein class B 1; Basic helix loop helix protein class B 1; BHLHB; bHLHB1; bHLHe19; Class B basic helix loop helix protein 1; Class B basic helix-loop-helix protein 1; class E basic helix loop helix protein 19; Class E basic helix-loop-helix protein 19; Human protein kinase C binding protein RACK17; Olig2; OLIG2_HUMAN; Oligo2; Oligodendrocyte lineage transcription factor 2; Oligodendrocyte specific bHLH transcription factor 2; Oligodendrocyte transcription factor 2; OTTHUMP00000067569; OTTHUMP00000067570; PRKCBP2; Protein kinase C binding protein 2; Protein kinase C binding protein RACK17; Protein kinase C-binding protein 2; Protein kinase C-binding protein RACK17; RACK17.
Dilution WB~~1:1000
Format Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name OLIG2
Synonyms BHLHB1, BHLHE19, PRKCBP2, RACK17
Function Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}. Cytoplasm. Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2
Tissue Location Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
Research Areas

BACKGROUND

Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity).

REFERENCES

Kuroda S.,et al.Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
Wang J.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:3497-3502(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Marie Y.,et al.Lancet 358:298-300(2001).
Lu Q.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:10851-10856(2001).

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