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CBR1 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - CBR1 Antibody AP52770
    Western blot detection of CBR1 in Hela,A431 and MDA-MB-468 cell lysates using CBR1 mouse mAb (1:1000 diluted).Predicted band size:30KDa,Observed band size:30KDa.
  • 8 - CBR1 Antibody AP52770
    Immunocytochemistry stain of Hela using CBR1 mouse mAb (1:100).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, ICC
Primary Accession P16152
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 30 KDa
Additional Information
Gene ID 873
Other Names 15 hydroxyprostaglandin dehydrogenase [NADP ];15-hydroxyprostaglandin dehydrogenase [NADP ];Carbonyl reductase [NADPH] 1;CBR 1;CBR1;CBR1_HUMAN;CRN;NADPH dependent carbonyl reductase 1;NADPH-dependent carbonyl reductase 1;Prostaglandin 9 ketoreductase; Prostaglandin 9-ketoreductase;Prostaglandin E(2) 9 reductase;Prostaglandin-E(2) 9-reductase;SDR21C1.
Dilution WB~~1:1000
ICC~~1:100
Format Purified mouse monoclonal in PBS(pH 7.4)containing with 0.02% sodium azide,50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name CBR1
Synonyms CBR, CRN
Function NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
Cellular Location Cytoplasm.
Research Areas

BACKGROUND

NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.

REFERENCES

Wermuth B.,et al.J. Biol. Chem. 263:16185-16188(1988).
Forrest G.L.,et al.Biochim. Biophys. Acta 1048:149-155(1990).
Forrest G.L.,et al.Mol. Pharmacol. 40:502-507(1991).
Watanabe K.,et al.Genomics 52:95-100(1998).
Terada T.,et al.Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.

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