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SWAP70 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - SWAP70 Antibody AP52767
    Western blot detection of SWAP70 in COS7,293T,C6,3T3 and Hela cell lysates and using SWAP70 mouse mAb (1:1000 diluted).Predicted band size: 70KDa.Observed band size: 70KDa.
  • 5 - SWAP70 Antibody AP52767
    Immunoprecipitation analysis of Hela cell lysate using SWAP70 mouse mAb.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IP
Primary Accession Q9UH65
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Calculated MW 70 KDa
Additional Information
Gene ID 23075
Other Names KIAA0640;70kDa;AV235546;FLJ39540;HSPC321;SWA 70 protein;SWAP 70;SWAP switching B-cell complex 70kDa subunit;SWAP-70;SWAP70;Switch associated protein 70;Switch-associated protein 70;SWP70_HUMAN.
Dilution WB~~1:1000
IP~~1:500
Format Ascites
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name SWAP70
Synonyms KIAA0640
Function Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
Cellular Location Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia
Tissue Location Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus- associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760)
Research Areas

BACKGROUND

Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).

REFERENCES

Masat L.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:2180-2184(2000).
Rapalus L.,et al.Clin. Immunol. 101:270-275(2001).
Monz D.W.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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