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FYB Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - FYB Antibody AP52751
    Western blot detection of FYB in 10,20 and 30ug Jurkat cell lysate using FYB mouse mAb (1:500 diluted).Predicted band size:120KDa.Observed band size:120KDa.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession O15117
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 120 KDa
Additional Information
Gene ID 2533
Other Names ADAP;Adhesion and degranulation promoting adaptor protein;FYB 120/130;Fyb;FYB-120/130; FYB_HUMAN;FYN binding protein;FYN T binding protein;FYN-binding protein;FYN-T-binding protein;p120/p130;PRO0823;SLAP 130;SLAP-130;SLAP130;SLP 76 associated phosphoprotein; SLP-76-associated phosphoprotein;SLP76 associated phosphoprotein.
Dilution WB~~1:500
Format Ascites containing with 0.02% sodium azide and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name FYB
Synonyms SLAP130
Function Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.
Cellular Location Cytoplasm. Nucleus
Tissue Location Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues
Research Areas

BACKGROUND

Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.

REFERENCES

da Silva A.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:7493-7498(1997).
Musci M.A.,et al.J. Biol. Chem. 272:11674-11677(1997).
Krause M.,et al.J. Cell Biol. 149:181-194(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).

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