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>   首页   >   产品   >   一抗   >   细胞生物学   >   RanBP9 Antibody   

RanBP9 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - RanBP9 Antibody AP52736
    Western blot detection of RanBP9 in Jurkat,MOLT-4 and CEM cell lysates and using RanBP9 mouse mAb (1:1000 diluted).Predicted band size: 78KDa.Observed band size: 95KDa.
  • 8 - RanBP9 Antibody AP52736
    Immunocytochemistry stain of Hela using RanBP9 mouse mAb (1:300).
  • 5 - RanBP9 Antibody AP52736
    Immunoprecipitation analysis of Hela cell lysates using RanBP9 mouse mAb.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, ICC, IP
Primary Accession Q96S59
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 78 KDa
Additional Information
Gene ID 10048
Other Names B cell antigen receptor Ig beta associated protein 1;BPM 90;BPM L;BPM-L;BPM90;BPML;IBAP 1;Imp 9;Importin 9;Novel centrosomal protein RanBPM;RAN binding protein 9;Ran binding protein centrosomal;Ran Binding Protein in the Microtubule organizing center;Ran binding protein M;Ran BP9; Ran-binding protein 9;Ran-binding protein M;RANB9_HUMAN;RanBP 7;RANBP 9;RanBP7;RanBP9;RanBPM.
Dilution WB~~1:1000
ICC~~1:300
IP~~1:500
Format Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name RANBP9
Synonyms RANBPM
Function May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA (By similarity).
Cellular Location Cytoplasm, cytosol. Nucleus. Note==Predominantly cytoplasmic. A phosphorylated form is associated with the plasma membrane
Tissue Location Ubiquitously expressed, with highest levels in testes, placenta, heart, and muscle, and lowest levels in lung Within the brain, expressed predominantly by neurons in the gray matter of cortex, the granular layer of cerebellum and the Purkinje cells.
Research Areas

BACKGROUND

May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA (By similarity).

REFERENCES

Nishitani H.,et al.Gene 272:25-33(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Nakamura M.,et al.J. Cell Biol. 143:1041-1052(1998).
Wang Y.,et al.Biochem. Biophys. Res. Commun. 297:148-153(2002).

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