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GRK2 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - GRK2 Antibody AP52726
    Western blot detection of GRK2 in Ramos and THP-1 cell lysates using GRK2 mouse mAb (1:500 diluted),with super ECL.Predicted band size:80KDa.Observed band size:80KDa.Exposure time:20S.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P25098
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 80 KDa
Additional Information
Gene ID 156
Other Names ADRBK 1;ADRBK1;Adrenergic beta receptor kinase 1;Adrenergic beta receptor kinase 1; ARBK1_HUMAN;BARK 1;BARK;BARK1;Beta adrenergic receptor kinase 1;Beta ARK 1;Beta ARK1; Beta-adrenergic receptor kinase 1;Beta-ARK-1;FLJ16718;G Protein Coupled Receptor Kinase 2;G protein dependent receptor kinase 2;G-protein coupled receptor kinase 2;GRK 2;GRK2.
Dilution WB~~1:500
Format Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name ADRBK1
Synonyms BARK, BARK1, GRK2
Function Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:P21146}. Cell membrane {ECO:0000250|UniProtKB:P21146}
Tissue Location Expressed in peripheral blood leukocytes.
Research Areas

BACKGROUND

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

REFERENCES

Benovic J.L.,et al.FEBS Lett. 283:122-126(1991).
Chuang T.T.,et al.J. Biol. Chem. 267:6886-6892(1992).
Penn R.B.,et al.J. Biol. Chem. 269:14924-14930(1994).
Aragay A.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:2985-2990(1998).
Oppermann M.,et al.J. Biol. Chem. 274:8875-8885(1999).

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